Ib txoj hauv kev mob qog noj ntshav zais ntawm lub cev lub cev tiv thaiv kab mob yog los ntawm kev tsim cov txheej txheem nyias nyias hu ua glycocalyx. Hauv txoj kev tshawb fawb tshiab, cov kws tshawb fawb tau tshuaj xyuas cov khoom siv ntawm qhov teeb meem no nrog kev daws teeb meem tsis tau pom dua, nthuav tawm cov ntaub ntawv uas tuaj yeem pab txhim kho kev tiv thaiv kab mob qog noj ntshav tam sim no.
Cov qog nqaij hlav qog nqaij hlav feem ntau tsim cov glycocalyx nrog cov qib siab ntawm cov cell mucins, uas tau xav tias yuav pab tiv thaiv cov qog nqaij hlav los ntawm kev tawm tsam los ntawm lub cev tiv thaiv kab mob. Txawm li cas los xij, kev nkag siab ntawm lub cev ntawm qhov teeb meem no tseem txwv, tshwj xeeb tshaj yog hais txog kev kho mob qog noj ntshav cellular immunotherapy, uas cuam tshuam nrog tshem tawm cov kab mob tiv thaiv kab mob los ntawm tus neeg mob, hloov kho lawv los nrhiav thiab rhuav tshem cov qog nqaij hlav, thiab tom qab ntawd tig rov qab mus rau tus neeg mob.
"Peb pom tias qhov kev hloov pauv ntawm qhov thaiv qhov tuab me me li 10 nanometers cuam tshuam rau kev ua haujlwm antitumor ntawm peb lub cev tiv thaiv kab mob lossis cov tshuaj tiv thaiv kab mob tiv thaiv kab mob," said Sangwu Park, tus kawm tiav hauv Matthew Paszek lab ntawm Cornell University ntawm ISAB, New York. "Peb tau siv cov ntaub ntawv no los tsim cov kab mob tiv thaiv kab mob uas tuaj yeem dhau los ntawm glycocalyx, thiab peb cia siab tias txoj hauv kev no tuaj yeem siv los txhim kho cov kab mob tiv thaiv kab mob niaj hnub no." Biology.
"Peb lub chaw kuaj mob tau los nrog lub tswv yim muaj zog hu ua scanning angle interference microscopy (SAIM) los ntsuas nanosized glycocalyx ntawm cov qog nqaij hlav cancer," said Park. "Cov txheej txheem kev yees duab no tso cai rau peb nkag siab txog kev sib raug zoo ntawm cov kab mob qog noj ntshav nrog rau cov khoom siv biophysical ntawm glycocalyx."
Cov kws tshawb fawb tau tsim cov qauv cellular los tswj cov kev qhia ntawm cov cell nto mucins kom ua raws li glycocalyx ntawm cov qog nqaij hlav cancer. Lawv mam li muab cov lus qhia caj ces los tshawb xyuas qhov chaw ua kom tuab li, thiab hla cov qog nqaij hlav cancer cuam tshuam rau kev cuam tshuam nanoscale kev cuam tshuamickness. Lawv kuj tau soj ntsuam seb qhov tuab ntawm glycocalyx cuam tshuam li cas ntawm cov hlwb kom tawm tsam los ntawm lub cev tiv thaiv kab mob.
Txoj kev tshawb no qhia tau hais tias qhov tuab ntawm cov qog nqaij hlav qog nqaij hlav glycocalyx yog ib qho ntawm cov tsis tseem ceeb uas txiav txim siab txog kev tiv thaiv kab mob hauv lub cev, thiab cov tshuaj tiv thaiv kab mob ua haujlwm tau zoo dua yog tias glycocalyx nyias.
Raws li qhov kev paub no, cov kws tshawb fawb tau tsim cov kab mob tiv thaiv kab mob nrog cov enzymes tshwj xeeb ntawm lawv qhov chaw uas tso cai rau lawv txuas rau thiab cuam tshuam nrog glycocalyx. Kev sim ntawm qib cellular tau pom tias cov kab mob tiv thaiv kab mob no tuaj yeem kov yeej glycocalyx armor ntawm cov qog nqaij hlav cancer.
Cov kws tshawb fawb tom qab ntawd npaj los txiav txim seb cov txiaj ntsig no puas tuaj yeem rov ua dua hauv chav kuaj thiab thaum kawg hauv kev sim tshuaj.
Sangwoo Park yuav nthuav tawm txoj kev tshawb no (cov ntsiab lus) thaum lub sij hawm "Regulatory Glycosylation in the Spotlight" session on Sunday, March 26, 2-3 pm PT, Seattle Convention Center, room 608. Hu rau pab neeg xov xwm yog xav paub ntxiv los yog pub dawb mus rau lub kev sib tham.
Nancy D. Lamontagne yog tus kws sau ntawv tshawb fawb thiab kws kho mob ntawm Creative Science Writing hauv Chapel Hill, North Carolina.
Sau koj tus email chaw nyob thiab peb yuav xa koj cov ntawv tshiab, kev xam phaj thiab ntau ntxiv txhua lub lim tiam.
Ib txoj kev tshawb fawb tshiab hauv Pennsylvania tau tso lub teeb pom kev ntawm cov protein tshwj xeeb qhib cov txheej txheem nruj ntawm cov khoom siv caj ces rau kev siv.
Lub Tsib Hlis yog Huntington's Disease Awareness Month, yog li cia peb saib seb nws yog dab tsi thiab qhov twg peb tuaj yeem kho nws.
Penn State cov kws tshawb fawb tau pom tias cov receptor ligand khi rau qhov kev hloov pauv thiab txhawb kev noj qab haus huv ntawm plab.
Cov kws tshawb fawb pom tau hais tias phospholipid derivatives nyob rau hauv Western noj zaub mov pab kom nce qib ntawm plab hnyuv kab mob co toxins, kab mob, thiab atherosclerotic plaque tsim.
Kev txhais lus tseem ceeb "barcode". Cleavage ntawm cov protein tshiab hauv cov kab mob hlwb. Lub ntsiab molecules ntawm lipid droplet catabolism. Nyeem cov lus tseeb txog cov ncauj lus no.
Post lub sij hawm: May-22-2023